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Ling Dai, Xiang Gao, Zhihua Ye, Hanmin Li, Xin Yao, Dingbo Lu, Na Wu
《医学前沿(英文)》 2021年 第15卷 第3期 页码 495-505 doi: 10.1007/s11684-020-0790-9
关键词: hepatitis B virus-related liver failure traditional Chinese medicine liver regeneration liver regeneration microenvironment cytokines
null
《医学前沿(英文)》 2018年 第12卷 第3期 页码 262-268 doi: 10.1007/s11684-017-0584-x
γδ T cells display unique developmental, distributional, and functional patterns and can rapidly respond to various insults and contribute to diverse diseases. Different subtypes of γδ T cells are produced in the thymus prior to their migration to peripheral tissues. γδ T cells are enriched in the liver and exhibit liver-specific features. Accumulating evidence reveals that γδ T cells play important roles in liver infection, non-alcoholic fatty liver disease, autoimmune hepatitis, liver fibrosis and cirrhosis, and liver cancer and regeneration. In this study, we review the properties of hepatic γδ T cells and summarize the roles of γδ T cells in liver diseases. We believe that determining the properties and functions of γδ T cells in liver diseases enhances our understanding of the pathogenesis of liver diseases and is useful for the design of novel γδ T cell-based therapeutic regimens for liver diseases.
关键词: γδT cells liver infection non-alcoholic fatty liver disease autoimmune hepatitis liver fibrosis and cirrhosis liver cancer liver regeneration
Liver cell therapies: cellular sources and grafting strategies
《医学前沿(英文)》 2023年 第17卷 第3期 页码 432-457 doi: 10.1007/s11684-023-1002-1
关键词: liver regeneration hepatocytes cholangiocytes stem cells organoids regulatory mechanisms transplantation/grafting strategies
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《医学前沿(英文)》 2011年 第5卷 第1期 页码 1-7 doi: 10.1007/s11684-010-0105-7
Partial liver transplantation, including reduced-size liver transplantation, split liver transplantation, and living donor liver transplantation, has been developed with several innovative techniques because of donor shortage. Reduced-size liver transplantation is based on Couinaud’s anatomical classification, benefiting children and small adult recipients but failing to relieve the overall donor shortage. Split liver transplantation provides chances to two or even more recipients when only one liver graft is available. The splitting technique must follow stricter anatomical and physiological criteria either ex situ or in situto ensure long-term quality. The first and most important issue involving living donor liver transplantation is donor safety. Before surgery, a series of donor evaluations—including anatomical, liver volume, and liver function evaluations—is indispensable, followed by ethnic agreement. At different recipient conditions, auxiliary liver transplantation and auxiliary partial orthotopic liver transplantation, which employ piggyback techniques, are good alternatives. Partial liver transplantation enriches the practice and knowledge of the transplant society.
关键词: partial liver transplantation reduced-size liver transplantation split liver transplantation living donor liver transplantation
Migration of manganese and iron during the adsorption-regeneration cycles for arsenic removal
Fangfang CHANG, Jiuhui QU, Xu ZHAO, Wenjun LIU, Kun WU
《环境科学与工程前沿(英文)》 2011年 第5卷 第4期 页码 512-518 doi: 10.1007/s11783-011-0372-9
Bin Yu, Xiaosong Gu
《医学前沿(英文)》 2019年 第13卷 第2期 页码 131-137 doi: 10.1007/s11684-018-0642-z
关键词: spinal cord injury biomaterial extrinsic barrier intrinsic regeneration capacity
Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region
Zhiyuan Zhang
《医学前沿(英文)》 2011年 第5卷 第4期 页码 401-413 doi: 10.1007/s11684-011-0161-7
关键词: bone regeneration animal models translational strategies oral and maxillofacial region
SHI Mingheng, DU Bin, ZHAO Yun
《能源前沿(英文)》 2007年 第1卷 第1期 页码 85-90 doi: 10.1007/s11708-007-0008-8
关键词: desiccant air-conditioning regeneration process air-conditioning system energy regeneration
Evaluation of power regeneration in primary suspension for a railway vehicle
Ruichen WANG, Zhiwei WANG
《机械工程前沿(英文)》 2020年 第15卷 第2期 页码 265-278 doi: 10.1007/s11465-019-0571-9
关键词: railway vehicle primary damper power regeneration ride comfort running safety
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《医学前沿(英文)》 2018年 第12卷 第3期 页码 249-261 doi: 10.1007/s11684-018-0622-3
Natural killer T cells are innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the liver. Natural killer T cells play important roles in infections, tumors, autoimmune diseases, and metabolic diseases. In this study, we summarize recent findings on biology of natural killer T cells and their roles in hepatitis B virus and hepatitis C virus infection, autoimmune liver diseases, alcoholic liver disease, nonalcoholic fatty liver disease, and hepatocellular carcinoma. Controversial results from previous studies are discussed, and indicate the dynamic alteration in the role of natural killer T cells during the progression of liver diseases, which might be caused by changes in natural killer T subsets, factors skewing cytokine responses, and intercellular crosstalk between natural killer T cells and CD1d-expressing cells or bystander cells.
关键词: natural killer T cells hepatitis B virus and hepatitis C virus infection autoimmune liver diseases alcoholic liver disease nonalcoholic fatty liver disease hepatocellular carcinoma
Natural killer cells in liver diseases
null
《医学前沿(英文)》 2018年 第12卷 第3期 页码 269-279 doi: 10.1007/s11684-018-0621-4
The liver has been characterized as a frontline lymphoid organ with complex immunological features such as liver immunity and liver tolerance. Liver tolerance plays an important role in liver diseases including acute inflammation, chronic infection, autoimmune disease, and tumors. The liver contains a large proportion of natural killer (NK) cells, which exhibit heterogeneity in phenotypic and functional characteristics. NK cell activation, well known for its role in the immune surveillance against tumor and pathogen-infected cells, depends on the balance between numerous activating and inhibitory signals. In addition to the innate direct “killer” functions, NK cell activity contributes to regulate innate and adaptive immunity (helper or regulator). Under the setting of liver diseases, NK cells are of great importance for stimulating or inhibiting immune responses, leading to either immune activation or immune tolerance. Here, we focus on the relationship between NK cell biology, such as their phenotypic features and functional diversity, and liver diseases.
关键词: natural killer cell phenotype immune activation immune tolerance liver diseases
Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea
null
《医学前沿(英文)》 2016年 第10卷 第3期 页码 237-249 doi: 10.1007/s11684-016-0464-9
Sensory hair cells in the inner ear are responsible for sound recognition. Damage to hair cells in adult mammals causes permanent hearing impairment because these cells cannot regenerate. By contrast, newborn mammals possess limited regenerative capacity because of the active participation of various signaling pathways, including Wnt and Notch signaling. The Wnt and Notch pathways are highly sophisticated and conserved signaling pathways that control multiple cellular events necessary for the formation of sensory hair cells. Both signaling pathways allow resident supporting cells to regenerate hair cells in the neonatal cochlea. In this regard, Wnt and Notch signaling has gained increased research attention in hair cell regeneration. This review presents the current understanding of the Wnt and Notch signaling pathways in the auditory portion of the inner ear and discusses the possibilities of controlling these pathways with the hair cell fate determiner Atoh1 to regulate hair cell regeneration in the mammalian cochlea.
关键词: inner ear cochlea hair cell regeneration Wnt Notch signaling pathways
Assessment of liver volume variation to evaluate liver function
null
《医学前沿(英文)》 2012年 第6卷 第4期 页码 421-427 doi: 10.1007/s11684-012-0223-5
In order to assess the value of liver volumetry in cirrhosis and acute liver failure (ALF) patients, we explored the correlation between hepatic volume and severity of the hepatic diseases. The clinical data of 48 cirrhosis patients with 60 normal controls and 39 ALF patients were collected. Computed tomography-derived liver volume (CTLV) and body surface area (BSA) of normal controls were calculated to get a regression formula for standard liver volume (SLV) and BSA. Then CTLV and SLV of all patients were calculated and grouped by Child-Turcotte-Pugh classification for cirrhosis patients and assigned according to prognosis of ALF patients for further comparison. It turned out that the mean liver volume of the control group was 1 058±337 cm3. SLV was correlated with BSA according to the regression formula. The hepatic volume of cirrhosis patients in Child A, B level was not reduced, but in Child C level it was significantly reduced with the lowest liver volume index (CTLV/SLV). Likewise, in the death group of ALF patients, the volume index was significantly lower than that of the survival group. Based on volumetric study, we proposed an ROC (receiver operating characteristic) analysis to predict the prognosis of ALF patients that CTLV/SLV<83.9% indicates a poor prognosis. In conclusion, the CTLV/SLV ratio, which reflects liver volume variations, correlates well with the liver function and progression of cirrhosis and ALF. It is also a very useful marker for predicting the prognosis of ALF.
关键词: liver volume variation cirrhosis acute liver failure (ALF)
Electro-assisted regeneration of ion exchange resins
LIU Zhigang, WANG Ying, LI Yansheng, CHANG Hui
《环境科学与工程前沿(英文)》 2008年 第2卷 第4期 页码 410-414 doi: 10.1007/s11783-008-0069-x
关键词: effluent volume acidic three-compartment weakly exchange
Sulfidation/regeneration multicycle testing of nickel-modified ZnFe
Wei LI, Jinju GUO, Jiejie HUANG, Jiaotao ZHAO
《化学科学与工程前沿(英文)》 2010年 第4卷 第4期 页码 435-440 doi: 10.1007/s11705-010-0506-9
关键词: hot gas desulphurization nickel-modified ZnFe2O4 sulfidation/regeneration
标题 作者 时间 类型 操作
The “Traditional Chinese medicine regulating liver regeneration” treatment plan for reducing mortalityof patients with hepatitis B-related liver failure based on real-world clinical data
Ling Dai, Xiang Gao, Zhihua Ye, Hanmin Li, Xin Yao, Dingbo Lu, Na Wu
期刊论文
Migration of manganese and iron during the adsorption-regeneration cycles for arsenic removal
Fangfang CHANG, Jiuhui QU, Xu ZHAO, Wenjun LIU, Kun WU
期刊论文
biomaterial transplantation and genetic enhancement of intrinsic growth capacities to promote CNS axon regeneration
Bin Yu, Xiaosong Gu
期刊论文
Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region
Zhiyuan Zhang
期刊论文
Investigation on regeneration and energy storage characteristics of a solar liquid desiccant air-conditioning
SHI Mingheng, DU Bin, ZHAO Yun
期刊论文
Evaluation of power regeneration in primary suspension for a railway vehicle
Ruichen WANG, Zhiwei WANG
期刊论文
Electro-assisted regeneration of ion exchange resins
LIU Zhigang, WANG Ying, LI Yansheng, CHANG Hui
期刊论文